So, I WAS missing something!
You were thinking specifically of virtual devices, but omitted to mention this in your question?
To answer your question, yes, I was thinking of some sort of cable. Is there such a thing as a virtual cable?
At one time, not so long ago, I had a virtual keyboard active (VMPK), and Virtual Midi Synth system active, and these were working fine and no DAW was involved, and as far as I'm aware, no 'intermediate software' (although as it was all virtual I couldn't be sure about that). The two processes just connected, and got on fine, although I maybe had to do a tiny 'introduction'. Then I needed to change the HD and the VMPK is no longer active, but the Virtual Synth etc is still there (with SynthFont ?)
Geoff